Name |
Expression |
MW |
Function |
Other Names |
Family |
CD101 |
mono, gran,DC, Tact |
120kD |
T cell activation |
V7, p126 |
IgSF |
CD102 |
lymph,
mono, platelets, endoth |
55-65kD |
binds
CD11a/CD18, costimulation |
ICAM-2 |
IgSF |
CD103 |
intraepithelial lymph, lymph subset, activated lymph |
150, 25kD |
w/ integrin
β7, binds E-cadherin, lymph homing/retention |
HML-1, α6,
integrin αE |
Integrin
family |
CD104 |
epith,
Schwann cells, keratinocytes, some tumor cells |
220kD |
w/ integrin
α6 (CD49f), cell adhesion, differentiation, metastasis |
β4 integrin |
Integrin
family |
CD105 |
endoth,
bone marrow subset, activated mac |
95kD |
cellular
response to TGF-β1 |
Endoglin |
homodimer |
CD106 |
activated
endoth, FDC |
110kD |
VLA-4(CD49d/CD29) receptor, leukocyte adhesion, migration,
costimulation |
VCAM-1 |
IgSF |
CD107a |
activated
platelets, T, endoth, metastatic tumors |
110kD |
a lysosomal
membrane protein |
LAMP-1 |
|
CD107b |
activated
platelets, T, endoth, metastatic tumors |
120kD |
a lysosomal
membrane protein |
LAMP-2 |
|
CD108 |
erythrocytes, lymphoblasts, resting lymph |
80kD |
|
|
|
CD109 |
T
and platelets, CD34+ subset, endoth |
170kD |
|
|
|
CD110 |
megakaryocytes, platelets, some CD34+ stem cells |
82-84kD |
thrombopoietin receptor, megakaryocyte progenitor cell
growth/differentiation |
MPL, TPO-R |
CRSF |
CD111 |
stem cell
subset, mac, neutrophils |
64-72kD |
|
PRR1,
Nectin-1 |
IgSF |
CD112 |
mono,
neutrophils, CD34+ subset, megakaryocytes, endoth, epith |
64-72kD |
intercellular adhesion |
PRR2,
Nectin-2 |
IgSF |
CDw113 |
testis,
placenta |
83kD |
adhesion
molecule that interacts with afadin |
PVRL3,
Nectin3 |
IgSF |
CD114 |
myeloid
progenitors, endoth |
95, 139kD |
myeloid
differentiation/proliferation |
G-CSFR |
CRSF |
CD115 |
mono, mac,
monocytic progenitors |
150kD |
CSF-1R,
monocytic differentiation/ proliferation |
M-CSFR,
c-fms |
IgSF, RTK
family |
CD116 |
mono, gran,
DC, endoth |
70-85kD |
w/ common β,
myeloid differentiation/proliferation |
GM-CSFRα |
CRSF |
CD117 |
hematopoietic progenitors, mast cells |
145kD |
SCF
receptor, hematopoietic progenitor development/differentiation |
c-kit, SCFR |
IgSF, RTK
family |
CD118 |
epithelial
cells in adult and embryo |
190kD |
membrane-bound involved in signal transduction, soluble form
inhibits activity of LIF |
LIFR, gp190 |
Type I CRSF
& secreted forms |
CDw119 |
mac, mono,
B, T, NK, neutrophils, endoth |
90-100kD |
IFN-γ Rα, w/
IFN-γ AF-1, host defense |
IFNγR |
|
CD120a |
hematopoietic, non-hematopoietic cells |
50-60kD |
receptor for
both TNF-α and TNF-β |
TNFR-I |
TNFRSF |
CD120b |
hematopoietic, non-hematopoietic cells |
75-85kD |
receptor for
both TNF-α and TNF-β |
TNFR-II |
TNFRSF |
CD121a |
dimly
expressed on many cells |
80kD |
binds IL-1α
and IL-1β, IL-1 signaling |
IL-1R type I |
IgSF |
CDw121b |
B, mac,
mono, T subset |
60-70kD |
binds IL-1α
and IL-1β, negative signals |
IL-1R, type
II |
IgSF |
CD122 |
NK, T, B,
mono |
75kD |
IL-2Rβ and
IL-15Rβ, signal transduction |
IL-2Rβ |
CRSF |
CDw123 |
lymph
subset, basophils, hematopoietic progenitors, mac, DC,
megakaryocytes |
70kD |
IL-3Rα, w/
CDw131 |
IL-3R |
CRSF |
CD124 |
lymph,
mono, hematopoietic precursors, .broblast, epith |
140kD |
IL-4Rα, w/
CD132 or IL-13Rα, T cell growth/differentiation |
IL-4R |
CRSF |
CDw125 |
eosinophils, basophils |
60kD |
IL-5Rα, w/
CDw131 |
IL-5R |
CRSF |
CD126 |
B
and plasma cells, most leukocytes,
fibroblasts |
80kD |
IL-6Rα, w/
CD130 |
IL-6R |
IgSF, CRSF |
CD127 |
T, pro-B |
65-75kD |
IL-7Rα, w/
CD132, B and T cell development |
IL-7R |
CRSF |
CDw128 |
|
|
|
see CD181 &
CD182 |
|
CD130 |
Bact
and plasma cells, most leukocyteslow,
endoth |
130kD |
IL-6Rβ,
IL-6, IL-11, LIF, CNF signals |
IL-6Rβ,
gp130 |
CRSF |
CDw131 |
mono, gran,
early B |
95-120kD |
w/ α
subunits of IL-3R, IL-5R, and GM-CSFR, signal transduction |
IL-3R common
β |
CRSF |
CD132 |
T, B, NK,
mono, gran |
64kD |
subunit of
IL-2R, IL-4R, IL-7R, IL-9R, and IL-15R, signal transduction |
Common γ |
CRSF |
CD133 |
hematopoietic stem cell subset, epith, endoth |
120kD |
|
AC133,
prominin-like 1 |
TM5SF |
CD134 |
Tact |
48-50kD |
T cell
activation, differentiation, apoptosis |
OX-40 |
TNFRSF |
CD135 |
myelomonocytic, primitive B progenitors |
130-150kD |
tyrosine
kinase, binds FLT3 ligand, early lymph development |
Flt3/Flk2 |
RTK family |
CDw136 |
epith, CNS,
PNS, hematopoietic subset |
180kD |
migration,
morphological change and proliferation of different target cells |
MSP-R, RON |
RTK family |
CDw137 |
Tact |
30kD |
T
costimulation |
4-1BB |
TNFRSF |
CD138 |
plasma
cells, pre-B, basolateral surface of epith, meurons |
80-150kD |
receptor for
ECM, cell morphology |
Syndecan-1 |
Syndecan
family |
CD139 |
B, mono,
gran, erythrocyteslow |
228kD |
|
|
|
CD140a |
fibroblasts, smooth muscle & glial cells, chondrocytes |
180kD |
binds PDGF A
and B |
PDGFRα |
RTK family |
CD140b |
fibroblasts, smooth muscle & glial cells, chondrocytes |
180kD |
binds PDGF B |
PDGFRβ |
RTK family |
CD141 |
mono,
neutrophils, endoth, smooth muscle cells |
100kD |
initiation
of protein C anticoagulant signal |
Thrombomodulin |
C-type
lectin |
CD142 |
mono,
endoth, keratinocytes, epith |
45kD |
binds
clotting factor VIIa, initiator of clotting |
Tissue
Factor |
|
CD143 |
endoth,
epith, neurons, fibroblasts, activated mac |
170kD |
angiotensin
converting enzyme, angiotensin II & bradykinin metabolism |
ACE |
|
CD144 |
endoth |
130kD |
adhesion,
cell-cell interaction |
VE-Cadherin,
Cadherin-5 |
Cadherin
family |
CDw145 |
endoth,
some stromal cells |
110, 90kD |
|
|
|
CD146 |
endoth,
melanomas, FDC, Tact |
113-118kD |
adhesion |
MUC18,
S-endo |
IgSF |
CD147 |
leukocytes,
erythrocytes, platelets, endoth |
|
adhesion |
Neurothelin,
basoglin |
IgSF |
CD148 |
gran, mono,
DC, T (high upon activation) |
240-260kD |
tyrosine
phosphatase R Type III |
HPTP-eta |
|
CD150 |
T subset
(high upon activation), B, DC, endoth |
75-95kD |
costimulation, proliferation, Ig production, measles virus receptor |
SLAM |
IgSF |
CD151 |
endoth,
megakaryocytes, platelets, epith |
32kD |
cell
adhesion |
PETA-3 |
|
CD152 |
Tact
and B |
33kD |
CD80 and
CD86 receptor, negative regulation of T cell costimulation |
CTLA-4 |
IgSF |
CD153 |
neutrophils, B, Tact
and mac |
40kD |
CD30 ligand,
T costimulation |
CD30L |
TNFSF |
CD154 |
Tact |
32-39kD |
CD40 ligand,
B and DC costimulation |
CD40L, gp39,
TRAP |
TNFSF |
CD155 |
mono, mac,
CD34+ thymocytes |
80-90kD |
Polio virus
receptor (PVR) |
PVR |
IgSF |
CD156a |
neutrophils, mono |
69kD |
leukocyte
extravasation |
ADAM8 |
|
CD156b |
broad |
100kD |
cleaves
membrane proteins (TNF, TGFα) to generate soluble forms |
TACE/ADAM 17 |
|
CDw156c |
lymphoid
organs, peripheral blood leukocyte, cartilage, chondrocytes and
fetal liver |
98kD |
proteolytic
cleavage of cell-surface molecules including Notch, TNF-α, APP and
ephrin-A2 |
ADAM10 |
Peptidase
M12B family |
CD157 |
gran, mono,
B progenitors, endoth |
42-45kD |
ADP-ribosyl-cyclic ADP-ribose hydrolase activities, pre-B cell
growth |
BST-1 |
|
CD158a |
NK subset,
T subset |
50-58kD |
inhibition
of NK cell cytolytic activity, MHC class-I specific NK receptor |
p58.1 |
IgSF, KIR
family |
CD158b |
NK subset,
T subset |
50-58kD |
inhibition
of NK cell cytolytic activity, MHC class-I specific NK receptor |
p58.2 |
IgSF, KIR
family |
CD159a |
T subset,
NK |
43kD |
w/ CD94, NK
cell receptor |
NKG2A |
|
CD159c |
NK |
40kD |
w/ MHC class
I HLA-E molecules, forms heterodimer with CD94 |
NKG2C |
Type II
C-Type Lectin |
CD160 |
NK subset,
T subset |
27kD |
costimulation |
BY55 |
IgSF |
CD161 |
T subset,
NK |
40kD |
NK
cell-mediated cytotoxicity |
NKR-P1A |
C-type
lectin |
CD162 |
mono, gran,
most lymph |
120kD |
CD62P, CD62L
ligand, adhesion, rolling |
PSGL-1 |
Mucin family |
CD162R |
NK subset |
|
|
PEN-5 |
CHO |
CD163 |
mono, mac |
|
|
130kD |
Scavenger
receptor SF |
CD164 |
hematopoietic progenitor cell-stromal cell interaction |
80kD |
|
MGC-24 |
epith, mono,
lymphlow,
bone marrow stromal cells, CD34+ erythroid progenitors |
CD165 |
adhesion,
thymocyte-thymic epith interaction |
42kD |
|
AD2, gp37 |
lymph
subset, mono, immature thymocytes, platelets |
CD166 |
neurons,
mono, epith, fibroblasts, Tact |
105kD |
CD6 ligand,
adhesion |
ALCAM |
IgSF |
CD167a |
epith,
myoblasts |
120kD |
tyrosine
kinase, adhesion to collagen |
DDR1 |
RTK family |
CD168 |
mono, T
subset, thymocyte subset, intracellularly in breast cancer cells |
84-88kD |
adhesion,
tumor migration, metastasis |
RHAMM |
|
CD169 |
tissue mac
subset |
185kD |
adhesion,
cell-cell and cell-matrix interactions, binds CD227 on breast cancer
cells and CD43 on T cells |
sialoadhesin, Siglec-1 |
IgSF,
sialoadhesins |
CD170 |
Mac subset,
neutrophils |
140kD |
adhesion |
Siglec-5,
CD33-like2 |
IgSF,
sialoadhesins |
CD171 |
CNS, PNS,
glial cells, mono, T subset, B, DC, several human tumor cells |
200-210kD |
kidney
morphogenesis, lymph node architecture, T costimulation,
neurohistogenesis, homotypic interaction, binds CD9, CD24, CD56,
CD142, CD166, integrins |
L1 |
IgSF |
CD172a |
mono, T
subset, stem cells |
110kD |
adhesion,
complex w/ CD47 |
SIRPγ |
|
CD172b |
mono and DC |
50kD |
negative
regulation of RTK-coupled signaling |
SIRPβ, SIRB1 |
IgSF |
CD172g |
mRNA: liver
and at lower levels in many tissues |
45-50kD |
binds CD47 |
SIRPγ,
SIRPB2 |
IgSF, ASV |
CD173 |
erythrocytes, stem cell subset, platelets |
|
|
Blood group
H type 2 |
CHO |
CD174 |
stem cells
subset, epith |
|
|
Lewis Y |
CHO |
CD175 |
stem cells
subset |
|
|
Tn |
CHO |
CD175s |
erythroblasts |
|
|
Sialyl-Tn |
CHO |
CD176 |
stem cell
subset |
|
|
Thomson
Friedrenreich Ag |
CHO |
CD177 |
neutrophil
subset |
56-62kD |
|
NB1 |
|
CD178 |
Tact,
testis |
38-42kD |
CD95 ligand,
apoptosis, immune privilege, soluble form in serum |
FasL, CD95L |
TNFSF |
CD179a |
Pro- and
Pre-B |
16-18kD |
B cell
differentiation/signaling, w/ IgM |
V pre B |
IgSF |
CD179b |
Pro- and
Pre-B |
22kD |
B cell
differentiation/signaling, w/ IgM |
Lambda 5 |
IgSF |
CD180 |
B subset,
mono, DC |
95-105kD |
B cell
activation, LPS signaling, w/ MD-1 |
RP-105 |
LRRF, TLR
family |
CD181 |
neutrophils, basophils, NK, T subset, mono |
39kD |
binding of
IL-8 induces chemotaxis of neutrophils |
CXCR1,
IL-8RA |
GPCR1 family |
CD182 |
neutrophils, basophils, NK, T subset, mono |
40kD |
binding of
IL-8 induces chemotaxis of neutrophils |
CXCR2,
IL-8RB |
GPCR1 family |
CD183 |
eosinophils, Tact
and NK, GM-CSF activated CD34+ progenitors |
40kD |
IP-10 , Mig
and I-TAC receptor, T cell recruitment to inflammatory sites,
enhancement of Th1 response |
CXCR3 |
TM7SF |
CD184 |
B, DC, T
subset, mono, endoth |
45kD |
SDF-1
receptor, X4 HIV-1 coreceptor |
CXCR4, fusin |
TM7SF |
CD185 |
mature B
and Burkitt Lymphoma cells |
45kD |
w/ chemokine
BLC, possible regulatory function in Burkitt Lymphomagenesis and/or
B differentiation, activation of mature B |
CXCR5, BLR1 |
GPCR1 family |
CDw186 |
Tact |
40kD |
receptor for
CXCL16 and coreceptor for SIV, strains of HIV-2 and m-tropic HIV-1 |
CXCR6, BONZO |
GPCR1 family |
CD191 |
T, mono,
stem cell subset |
39kD |
binds C-C
type chemokines and transduces signal by increasing intracellular
calcium ion levels |
CCR1,
MIP-1αR, RANTES-R |
GPCR1 family |
CD192 |
activated
NK and mononuclear phagocytes, T subset, B, endoth |
40kD |
binds MCP-1,
MCP-3 & MCP-4, alternative coreceptor with CD4 for HIV-1 infection |
CCR2,
MCP-1-R |
GPCR1 family |
CD193 |
eosinophils, lower expression in neutrophils and mono, T subset |
45kD |
binds
eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES & MIP-1δ, alternative
coreceptor w/ CD4 for HIV-1 infectiongg |
CCR3, CKR3 |
GPCR1 family |
CD195 |
mono, T
subset |
45kD |
MIP-1α,
MIP-1β and RANTES receptor, R5 HIV-1 coreceptor |
CCR5 |
|
CD196 |
T subset,
B, DC subset |
45kD |
binds
MIP-3α/LARC |
CCR6, LARC
receptor, DRY6 |
GPCR1 family |
CD197 |
T subset,
DC Subset |
45kD |
6Ckine and
MIP-2β receptor |
CCR7 |
|
CDw198 |
T, high
expression in Th2, NK, mono |
50kD |
allergic
inflammation, alternative coreceptor with CD4 for HIV-1 infection |
CCR8,
GPRCY6, TER1 |
GPCR1 family |
CDw199 |
subset of
memory T, lamina propria mononuclear cells |
43kD |
binds
SCYA25/TECK, alternative coreceptor with CD4 for HIV-1 infection |
CCR9,
GPR-9-6 |
GPCR1 family |
CD200 |
thymocytes,
endoth, B, Tact |
45-50kD |
inhibition
of immune response |
OX-2 |
|