| Name | Expression | M. W. | Functions | Other names | Family |
|---|---|---|---|---|---|
| CD1a CD1b CD1c CD1d |
Cortical thymocytes, Langerhans cells, Dendritic cells, B cells (CD1c), Intestinal epithelium (CD1d) | 43-49 | MHC class I-like molecule, associated with b2-microglobulin. May have specialised role in antigen presentation | Ig superfamily (IgSF) | |
| CD2 | T cells, thymocytes, NK cells | 45-58 | Adhesion molecule, binding CD58 (LFA-3). Can activate T cells | T11, LFA-2 | IgSF |
| CD2R | Activated T cells | 45-58 | activation-dependent conformational form of CD2 | T11-3 | IgSF |
| CD3 | Thymocytes, T cells | g:25-28 d:20 e:20 z:16 h:22 |
Associated with the T cell antigen receptor. Required for cell surface expression of and signal transduction by TCR. | T3 | IgSF (gde) z/h related to FcR g chain |
| CD4 | Thymocyte subsets, helper and inflammatory T cells (about two thirds of peripheral T cells), monocytes, macrophages | 55 | Coreceptor for MHC class II molecules. Binds lck on cytoplasmic face of membrane. Receptor for HIV-I and HIV-2 gp120. | T4, L3T4 | IgSF |
| CD5 | Thymocytes, T cells, subset of B cells | 67 | Binds to CD72 | T1, Ly1 | Scavenger receptor |
| CD6 | Thymocytes, T cells, B cell CLL | 100-130 | unknown. | T12 | Scavenger receptor |
| CD7 | Pluripotential hematopoietic cells, thymocytes, T cells | 40 | unknown. Marker for T cell ALL and pluripotential stem cell leukemias | IgSF | |
| CD8 | Thymocyte subsets, cytotoxic T cells (about one third of peripheral T cells) | a: 32-34 b: 32-34 |
Coreceptor for MHC class I molecules. Binds lck on cytoplasmic face of membrane | T8, Lyt2,3 | IgSF |
| CD9 | Pre-B cells, eosinophils, basophils, platelets | 22-27 | possible role in platelet aggregation and activation | tetraspanning membrane protein | |
| CD10 | B and T cell precursors, bone marrow stromal cells | 100 | zinc metalloproteinase, marker for pre B ALL | Neutral endopeptidase, Common Acute Lymphocytic Leukemia Antigen (CALLA) | |
| CD11a | lymphocytes, granulocytes, monocytes and macrophages | 180 | aL subunit of integrin LFA-1 (associated with CD18) ; binds to CD54 (ICAM-1), ICAM-2 and ICAM-3 | LFA-1 | |
| CD11b | myeloid and natural killer cells | 170 | aM subunit of integrin CR3 (associated with CD18) ; binds CD54, complement component iC3b and extracellular matrix proteins | Mac-1 | |
| CD11c | myeloid cells | 150 | aX subunit of integrin CR4 (associated with CD18) ; binds fibrinogen | CR4, p150, 95 |
|
| CDw12 | monocytes, granulocytes, platelets | 90-120 | unknown | ||
| CD13 | myelomonocytic cells | 150-170 | zinc metalloproteinase | amino peptidase N | |
| CD14 | myelomonocytic cells | 53-55 | receptor for complex of LPS and LPS binding protein (LBP) | ||
| CD15 & CD15S |
neutrophils, eosinophils, monocytes | branched pentasaccharide, expressed on glycolipids and many cell surface glycoproteins; the sialylated form is a ligand for CD62E (ELAM) | Lewsi-x (Lex) | ||
| CD16 a & b |
neutrophils, NK cells, macrophages | 50-80 | component of low affinity Fc receptor, FcgRIII, mediates phagocytosis and ADCC. | FcgRIII | IgSF |
| CDw17 | neutrophils, monocytes, platelets | lactosyl ceramide, a cell surface glycosphingolipid | |||
| CD18 | Leukocytes | 95 | integrin b2 subunit, associates with CD11a,b and c. | ||
| CD19 | B cells | 95 | forms complex with CD21 (CR2)and CD81 (TAPA-1); coreceptor for B cells | IgSF | |
| CD20 | B cells | 33-37 | possible role in regulating B cell activation | tetraspanning membrane protein | |
| CD21 | mature B cells, FDC | 145 | receptor for complement component C3d, EBV. With CD19 and CD81 forms coreceptor for B cells | CR2 | complement control protein (CCP) superfamily |
| CD22 | mature B cells | a: 130 b: 140 |
Adhesion of B cells to monocytes, T cells | BL-CAM | IgSF |
| CD23 | mature B cells, activated macrophages, eosinophils, follicular dendritic cells, platelets | 45 | low affinity receptor for IgE, ligand for CD19:CD21:CD81 coreceptor | FceRII | C-type lectin |
| CD24 | B cells, granulocytes | 35-45 | unknown | possible human homologue of mouse Heat Stable Antigen (HSA) or J11d. | |
| CD25 | activated T cells, B cells, monocytes | a:55 :b75 |
IL-2 receptor | Tac | a:CCP b: cytokine receptor superfamily |
| CD26 | Activated B and T cells, macrophages | 110 | protease. Recently implicated in HIV entry into cells. | Dipeptidyl peptidase IV | |
| CD27 | Medullary thymocytes, T cells | 50-55 | unknown | NGF receptor superfamily | |
| CD28 | T cell subsets, activated B cells | 44 | Activation of naive T cells, receptor for costimulatory signal (signal 2) binds CD80 (B7-1) and B7-2 | Tp44 | IgSF |
| CD29 | Leukocytes | 130 | Integrin b1 subunit, associates with CD49a in VLA-1 integrin | ||
| CD30 | Activated B and T cells | 105-120 | unknown | Ki-1 | NGF receptor superfamily |
| CD31 | monocytes, platelets, granulocytes, B cells, endothelial cells | 130-140 | Possibly an adhesion molecule | PECAM-1 | IgSF |
| CDw32 | Monocytes, granulocytes, B cells eosinophils | 40 | low affinity Fc receptor for aggregated Ig/immune complexes | FcgRII | IgSF |
| CD33 | myeloid progenitor cells, monocytes | 67 | unknown | IgSF | |
| CD34 | hematopoietic precursors, capillary endothelium | 105-120 | Ligand for CD62 (L-selectin) | ||
| CD35 | Erythrocytes, B cells, monocytes, neutrophils, eosinophils, FDC | 250 | Complement receptor 1, binds C3B and C4b, mediates phagocytosis | CR1 | CCP superfamily |
| CD36 | platelets, monocytes | 88 | unknown | platelet GPIV | |
| CD37 | mature B cells, mature T cells, myeloid cells | 40-52 | unknown | tetraspanning membrane protein | |
| CD38 | early B and T cells, activated T cells, germinal centre B cells, plasma cells | 45 | unknown | ||
| CD39 | activated B cells, activated NK cells, macrophages, dendritic cells | 78 | unknown, may mediate adhesion of B cells | ||
| CD40 | B cells, monocytes, dendritic cells | 50 | receptor for costimulatory signal for B cells, binds CD40 Ligand (T-BAM), | NGF receptor superfamily | |
| CD41 | platelets, megakaryocytes | 125/22 dimer | aIIb integrin, associates with CD61 to form GPIIb, binds fibrinogen, fibronectin, von Willebrand factor and thrombospondin | ||
| CD42a, b,c,d |
platelets, megakaryocytes | a: 23 b: 135, 23 c: 22 d: 85 |
binds von Willebrand factor, thrombin; essential for platelet adhesion at sites of injury | a: GPIX b: GPIba c: GPIbb d: GPV |
|
| CD43 | leukocytes, except resting B cells | 115-135 (PMN) 95-115 (T cells) |
binds CD54 (ICAM-1) | leukosialin, sialophorin | |
| CD44 | leukocytes, erythrocytes | 80-95 | binds hyaluronic acid, mediates adhesion of leukocytes | Hermes antigen, Pgp-1 | |
| CD45 | leukocytes | 180-240 | tyrosine phosphatase, augments signalling through antigen receptor of B and T cells, multiple isoforms result from alternative splicing (see below) | Leukocyte common antigen (LCA), T200, B220 | |
| CD45RO | T cell subsets, B cell subsets, monocytes, macrophages | 180 | isoform of CD45 containing none of the A, B and C exons | ||
| CD45RA | B cells, T cell subsets (naive T cells) monocytes | 205-220 | isoforms of CD45 containing the A exon | ||
| CD45RB | T cell subsets, B cells, monocytes, macrophages, granulocytes | 190-220 | isoforms of CD45 containing the B exon | T200 | |
| CD45RC | Restricted T200 | ||||
| CD46 | hematopoietic and non-hematopoietic nucleated cells | 56/66 (splice variants) | membrane cofactor protein, binds to C3b and C4b to permit their degradation by Factor I | MCP | CCP superfamily |
| CD47 | all cells | 47-52 | unknown, associated with Rh blood group | ||
| CD48 | leukocytes | 40-47 | unknown | Blast-1 | IgSF |
| CD49a | activated T cells, monocytes | 210 | a1 integrin, associates with CD29, binds collagen, laminin | VLA-1 | |
| CD49b | B cells, monocyte, platelets | 165 | a2 integrin, associates with CD29, binds collagen, laminin | VLA-2 | |
| CD49c | B cells | 125 | a3 integrin, associates with CD29, bindslaminin, fibronectin | VLA-3 | |
| CD49d | B cells, thymocytes | 150 | a4 integrin, associates with CD29, binds fibronectin, Peyer?s Patch HEV, VCAM-1 | VLA-4 | |
| CD49e | memory T cells, monocytes, platelets | 135, 25 dimer | a5 integrin, associates with CD29, binds fibronectin | VLA-5 | |
| CD49f | memory T cells, thymocytes, monocytes | 120, 25 dimer | a6integrin, associates with CD29, binds laminin | VLA-6 | |
| CD50 | thymocytes, T cells, B cells,monocytes, granulocytes | 130 | unknown | ICAM3 |
[Associations On-line Journals Literature Searches KO /Transgenic Mice Biotechnology Jobs CD antigens Immunology Books Products Grad- Programs Fellowship/ Grants Databases Advertise Contact Us]